In the 60's, the Puerto Rican Carlito Brigante, the Afro-American Earl and the Italian Rocco become best friends while in prison. When they are released, Rocco intermediates a heroin business with a family of the Italian Mafia leaded by Artie Badalato Sr. Carlito negotiates with the lord Leroy "Hollywood Nicky" Barnes the area where the trio could operate in his neighborhood and sooner the three friends become powerful. Later, Carlito dates and has an affair with the beautiful Leticia. When Earl decides to move to Barbados with his girlfriend and leave the heroin business, his stupid younger brother causes a situation with the Italian mobsters, and Carlito and Rocco have to resolve the mess to save their lives.

When Charlie meets Daphne - the girl of his dreams - he never expects he'll have to battle past her pet dog "Babydoll" to woo her. And just when it seems he can't beat the beast and all is lost, something unexpected happens: Charlie begins to fall in love with the dog himself, realizing he never really needed a girlfriend in the first place. Now, in order to keep hanging out with "man's best friend", Charlie must scramble to keep the relationship with Daphne going at all costs - or risk losing them both.

Following the tragic death of their two-year-old son Frankie, Irish couple Johnny and Sarah Sullivan and their remaining two offspring, 10 year old Christy Sullivan and 5 year old Ariel Sullivan, emigrate illegally to the United States via Canada with little in their pockets. Their final destination is Manhattan where Johnny hopes to work as a stage actor. They move into a unit in a run town tenement housed primarily with drug addicts, transvestites and one tenant coined "the man who screams". They do whatever they can to eke out a supportive family environment in this difficult situation, the support which ultimately extends to those around them, most specifically "the screamer" who turns out to be an African-American artist named Mateo with AIDS. But the memory of Frankie hangs over the family in good and bad ways, especially as Sarah learns she's pregnant. Christy...